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For example, in the STEP UP Diabetes trial, participants taking 7.2 mg of semaglutide weekly lost an average of 13.2% of their initial weight, compared to 10.4% for those on the standard 2.4 mg weekly dose

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Once bound to the antioxidant response element (ARE), Nrf2 upregulates cytoprotective genes such as Heme Oxygenase-1 (HO-1) and NAD(P)H: Quinone Oxidoreductase 1 (NQO1) (Kim et al., 2017