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Obesity as a Systemic Illness Lead investigator Kosiborod reflected on the obesity-phenotype HFpEF and the implications of STEP-HFpEF in the Intention to Treat podcast from the New England Journal of Medicine , saying: "We've been so conditioned, as cardiologists, to kind of think, when we see a patient with [HF], to see and think about the heart [as] being the primary cause of the problem that it hasn't occurred to us, as much as it should have, that in fact obesity is a systemic disease that affects multiple organ systems, and [the] heart is just one of them Even though the heart function is preserved, it hasn't occurred to us that this is actually just one of the manifestations of the systemic disease which is obesity

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