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At the highest dose, average weight loss reached 28.3%, suggesting comparisons of Retatrutide vs

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Due to tirzepatide's pharmacokinetic profile (peak concentration at approximately 24-48 hours and half-life of about 5 days), symptoms may persist for several days following a double dose, with effects potentially lasting longer than with shorter-acting GLP-1 receptor agonists

Jena, MD PhD Department of Health Care Policy, Harvard Medical School , Boston, MA Department of Medicine, Massachusetts General Hospital , Boston, MA National Bureau of Economic Research , Cambridge, MA, Nicholas Stucky, MD PhD Truveta, Inc , Bellevue, WA With the growing popularity of GLP-1 RAs, concerns have been raised that the expanded use may occur amongst patients with less clinical need