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The most common side effects are gastrointestinal, including nausea, diarrhea, vomiting, and constipation

all should be discontinued when pregnancy is recognized) [1] [4] After prolonged treatment interruptions (typically 2 consecutive missed doses or longer gaps), re-titration from the initial dose may be necessary according to product-specific guidelines to minimize gastrointestinal side effects

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doi:10.1177/25424823251388650 American Institute for Cancer Research