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GLP-1 and GIP receptor agonists seem to have a synergistic effect in weight reduction, although the mechanism is not yet clear [44]

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275,279 The results of others studies support this hypothesis, since high NAMPT protein and mRNA levels were observed when muscle cells were treated with the AMPK activator AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide)

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