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5 Discussion: perspective and open questions While the identification of RAiNs (Anton et al., 2022) and MERCS-associated signalosomes (Austin et al., 2025) defines the current frontier of incretin research, several critical gaps remain

Furthermore, weight reduction has been associated with enhanced psychological well-being and adherence to treatment regimens, as patients who experience weight loss may be more motivated to adopt healthier lifestyles, including regular physical activity and improved dietary habits [86]

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In some cases, individuals report persistent nausea, vomiting, malnutrition, and dehydration that require hospitalization or surgical intervention