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For the 9 mg target, doses increased in steps at 2 mg, 4 mg, and 6 mg, with increases every four weeks until reaching 9 mg

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Both PKA inhibitors (Rp-cAMP and H-89) and PI3 kinase inhibitors (LY294002 and wortmannin) partially suppressed the anti-apoptotic effect of GLP-1 on MG-induced apoptosis in both INS-1 and MIN6 cells (Fig