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When administered peripherally, particularly antibody-based GIPR antagonists demonstrate some potential to prevent the development of HFD-induced obesity in rodents (181, 186), but GIPR antagonists show only modest, if any ability to decrease body weight once obesity is already established (181, 183186)

Dose Escalation Is Not a Minor Detail The recruiting Phase 3 dose-escalation study deserves attention because tolerability often determines whether a protocol succeeds in real life

10.1016/j.amjmed.2025.01.021 Am J Med

Compounded semaglutide is generally recommended for patients with specific needs not met by commercially available products

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