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An emerging strategy to mitigate barriers related to NuSH therapy is microdosing, an off- label technique where lower or fractional doses are used to improve access, affordability, and/ or tolerability Microdosing GLP- 1RA and GIP/GLP- 1RA has been advertised by direct- to- consumer telehealth companies and on social media platforms and implemented in clinical practice without peer- reviewed, evidence- based guidance

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist with 94% structural homology to native GLP-1. It has demonstrated significant efficacy in glycemic control and weight management research applications