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Medicine , 6 (7), 102214

Study Design: Randomized controlled trials and observational cohort studies were included

Although our mouse studies suggest that tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the species difference in receptor pharmacology may limit extension of this interpretation to humans 25,26

Therefore, the reduction of foam cells with GLP-1RAs treatment is speculated to inhibit vascular senescence and delay the progression of atherosclerosis

Given the positive effects that GLP1 receptor agonists have on weight, significant interest exists in better understanding their potential role in managing osteoarthritis and associated pain
