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Not everyone in the first phase of the trial lost significant amounts of weight on the drug

Blood monocytes differentiate into several types of macrophages: classically activated types (M1) are pro-inflammatory and anti-fibrogenic, whereas alternatively activated M2 types are anti-inflammatory, pro-fibrogenic, and induce M1 cell apoptosis through IL-10 (Mosser and Edwards, 2008)

This introduces fabric fibers and surface bacteria

More significant weight loss typically develops over three to six months as dosing is gradually increased

Data from observational studies and subgroup analyses of RCTs show that GLP-1 RAs reduce HF outcomes and mortality in obese HF patients across the LVEF spectrum