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Development of GLP-1MK-801 To safely harness the weight-lowering properties of NMDA receptor antagonism, we developed a targeting approach based on the hypothesis that conjugation of MK-801 to a GLP-1 analogue through a chemically cleavable disulfide linker would enhance the therapeutic potential of NMDA receptor antagonism in appetite-regulating brain regions enriched for GLP-1 receptors, while mitigating the adverse effects related to the non-restricted actions of MK-801

Yanovski SZ, Yanovski JA

GLORY-3: A Phase 3 clinical study comparing mazdutide versus semaglutide in Chinese adults with overweight of obesity accompanied metabolic-associated fatty liver disease (MAFLD)

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The greatest neuroprotective effects were seen by the use of DA4-JC and DA-CH5 which improve motor function, protect dopaminergic neurons, reduce inflammation, and rescue glial cell line-derived neurotrophic factor levels [114]