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Zepbound (tirzepatide) is a dual GIP/GLP-1 receptor agonist that produced 20.9% mean weight loss at 72 weeks
The GLP-1-induced enhancement of evoked EPSCs was abolished by a selective GLP-1 receptor antagonist, exendin 939, as well as by the extracellular application of a specific protein kinase A (PKA) inhibitor, KT5720
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