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Description
Weight loss almost always includes a mixture of fat and lean tissue, which includes muscle and the ratio of fat to muscle loss matters a lot

Portal glucose infusion in the mouse induces hypoglycemia: evidence that the hepatoportal glucose sensor stimulates glucose utilization

From age 30, we lose muscle mass unless we actively train which accelerates VAT accumulation
Our related article on GLP-1 Signaling, the Microbiome, and Hormones explains why GLP-1 biology is part of a larger metabolic network rather than a stand-alone weight-loss switch

[DOI] [PMC free article] [PubMed] 72.Barber M
