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All these pathways eventually lead to an increase in the intracellular Ca 2+ concentration, thereby promoting the mitochondrial synthesis of ATP, and the release of insulin particles into the blood through exocytosis

Lower scores are better , thus the authors considered this data as potential evidence supporting slowing of disease progression

Protective cellular major antioxidant systems against cytotoxic effects are mitochondrial UCP and unfolded protein response (UPR) [128,135]

other from Allergan, Novartis, Cheisi and Amgen outside the submitted work

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