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Initially developed for glycaemic control and more recently approved for obesity management, GLP1RAs exhibit CNS activity that intersects with neurobiological pathways involved in mood regulation, reward processing and cognitive function

(2013) Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity

In summary, a series of GLP-1-based combination therapies has been found to offer metabolic benefits greater than what is achieved by treatment with each compound alone

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To exclude artifactual alterations by the FITC group, we performed kinetic-binding experiments with unlabeled agonists, in competition with exendin-4-FITC, and defined both association rate constants and residence times 43 with consistent effects (Fig