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Most treatment discontinuations were due to gastrointestinal AE and occurred during the rapid escalation phase this may be mitigated with more gradual dose escalation at phase 3 trials

The reasons for not losing weight on semaglutide are varied, but expired medication is one that people frequently overlook
Orforglipron, another Lilly tablet drug, is expected to gain FDA approval by the end of June

doi: 10.1016/j.molmet.2021.101240 88 LudwigMQChengWGordianDLeeJPaulsenSJHansenSNet al