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35 The incidence of hypoglycaemia was also significantly reduced at week 24
Upon activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), berberine enhances insulin sensitivity, reduces hepatic glucose output, and has been shown in animal models to increase GLP-1 secretion, although this mechanism has not yet been confirmed in large human trials
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The inclusion in another largely unexplored dimension, as the potential role it may have on the gut-microbiota-brain axis is also interesting
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