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OBJECTIVE: To investigate the effects of a near-physiological peripheral glucagon-like peptide-1 (GLP-1) infusion, during and after a breakfast of fixed energy content, on resting energy expenditure, substrate oxidation and metabolism and the desire to eat specific types of food in humans

Phase 2 clinical trials have demonstrated exceptional efficacy for weight reduction, with up to 24.2% weight loss at 48 weeks with the highest doseresults that exceed those typically observed with existing GLP-1 receptor agonists

Bariatric surgery is the most effective intervention for weight loss in obese patients, and it leads to improvement in multiple obesity-related conditions, including remission of diabetes.

The GLP-1 market is projected to exceed 100B USD by 2030

Discover what clinical evidence reveals about GLP-1 receptor agonists and thyroid cancer risk, who should exercise caution, and essential safety guidance for UK patients.