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Apitegromab (SRK-015), an investigational new drug developed by Scholar Rock, is a fully human IgG4 monoclonal antibody that specifically binds to human Pro-GDF8 or latent GDF8 without binding to mature GDF8 or other closely related growth factors
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Angioedema (non-pitting edema of submucosal tissues) results in infrequent, but high-risk emergency department visits
Huge congratulations to the authors!
