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The 6-day half-life supports once-weekly subcutaneous injection with stable plasma concentrations throughout the dosing interval

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Pulmonary embolism occurred in 207 of 117, 577 patients (0.18%) in the tirzepatide cohort and 960 of 117, 449 patients (0.82%) in the lifestyle cohort, corresponding to an RR of 0.215 (95% CI, 0.1850.250) and an OR of 0.214 (95% CI, 0.1840.249)