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Results of bariatric surgery in 24 children/adolescents PWS compared to 72 non-PWS subjects matched for age, gender and BMI, undergoing a laparoscopic sleeve gastrectomy, have recently been published [107]

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GLP-1 RAs reduced the composite outcome of all-cause mortality and HF hospitalization by 27% (HR 0.73

This was achieved by inhibiting bone resorption through an increase in the OPG/RANKL ratio and promoting bone formation by enhancing the expression of osteoblast-specific transcription factors

This reduction in stress can lead to improved sleep quality, allowing for deeper and more restorative rest