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The most common side effects of these drugs are mild gastrointestinal (GI) issues

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Tirzepatide was approved as a diabetes treatment in May of 2022

In fact, it is reported ( 50 5 pM, IC 50 0.76 nM) to wild-type GLP-1R than the native GLP-1 (EC 50 11 pM, IC 50 1 nM)

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