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Among these approaches, treatment with glucagon receptorcompetitive or allosteric antagonists (16) in clinical trials has been marked by side effects, including cell hyperplasia that exacerbates hyperglucagonemia and yields recurring of hyperglycemia (20), hyperlipidemia (21), elevation of plasma transaminases (22), and weight gain (23)
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Dose adjustments of concomitant diabetes medications may be necessary to prevent hypoglycemia
