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Pre-existing migraine history, medication sensitivity, dosing schedule, and individual metabolic responses all influence headache likelihood

The hypothalamus integrates hormonal signals that regulate appetite, energy expenditure, and metabolism

doi: 10.1038/nature11450 21 BrownJMHazenSL

The GPR84 GLP-1 mechanism described here has been demonstrated in mouse models and enteroendocrine cell lines (Nonaka et al., 2022
