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Wherein, PG is a protecting group selected from trityl (Trt), tert.butyl (t-Bu), Tosyl (Tos), monomethoxy trityl (Mmt), methyltrityl (Mtt), tert.butoxycarbonyl (Boc), 2,4- dimethylpent-3-yloxycarbonyl (Doc), benzyloxymethyl (Bom), tert-butoxymethyl (Bum)

Clinical outcomes continue to improve, and emerging evidence suggests potential reductions in healthcare utilization and long-term medical costs
N Engl J Med 345(12):851860 Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving H-H et al (2001Effects) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

Hamon and Blier, 2013)
