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Recognizing that the STEP-8 population may not fully represent the Greek obesity population, trial-based characteristics were reviewed and adapted using local epidemiological data and expert clinical opinion (e.g., smoking prevalence, hypertension, and diabetes distribution) to enhance relevance for the Greek setting

Furthermore, Black populations also experience significant cardiovascular benefits with GLP-1 analogs, although the differences are less pronounced than in Asians

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When that effect weakens, you notice it in specific ways

Most patients find that gastrointestinal symptoms diminish over time as the body adjusts to the medication, usually within 48 weeks
