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Treatment decisions, including dosing and monitoring strategies, should be individualized in consultation between patients and their physicians

This release of bile acids, mainly cholic (CA) and chenodeoxycholic (CDCA) acid derivatives, happens through the relaxation of the smooth muscle sphincter upon CCK signaling (336) or indirectly through a similar VIP action on the sphincter of Oddi (337)

In brief, this was a 52-week randomized, open-label, active-controlled, parallel-group, multicenter, phase 3a trial carried out in Japan

Circulation 142:12051218

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