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Additional evidence has indicated that GLP-1RAs elevated circulating irisin levels and BDNF (47, 48)

(0 = strong disliking, 50 = neither like nor dislike, and 100 = strong liking)

And its all thanks to the hypothalamus

From 10 to 15 mg, the additional loss is only 1.4 percentage points: the dose-response curve flattens

Moreover, these analyses have already been done in conventional meta-analyses, showing for SGLT-2 inhibitors the lack of significant difference in the reduced risk of the composite outcome (CV death + HHF) in patients with or without type 2 diabetes or in subjects of 65 years of age or younger vs those older than 65 years of age [13]