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There are several proposed hypotheses for how this occurs: Inside-out hypothesis: an endothelial-intimal disruption or flap develops first and then blood enters the sub-intimal space from the true lumen via this flap Outside-in hypothesis: a hematoma forms within the media, possibly from disruption of traversing micro-vessels, and compresses and occludes the true lumen as the hematoma expands

Larsen for expert technical assistance with conducting the animal studies

Melatonin not only effectively blocks the secondary injury process after SCI, but also promotes the recovery of intestinal microbiota structure

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