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Kelly SH, Wu Y, Varadhan AK, Curvino EJ, Chong AS, Collier JH

Standard dosing and titration schedules are often suitable across most CKD stages because these medications are not primarily metabolized by the kidneys , meaning reduced kidney function has minimal impact on how the body processes them

however, the same effect has not been replicated in large-scale human or primate studies [49]

Retatrutide is still unavailable outside of clinical trials, but that has not stopped a surge in illegal activity around the drug, with people claiming to buy and sell it on social media

When considering the initiation of these therapies, it is important to consider patient-specific factors