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When activated by medications like retatrutide, it slows gastric emptying, increases insulin secretion, reduces appetite, and (unexpectedly) affects liver enzyme expression including Cyp2e1

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Your healthcare team will typically perform several assessments before agreeing to discontinue Trulicity: Review your recent HbA1c results to understand your current level of glycaemic control Assess your cardiovascular risk factors , as GLP-1 receptor agonists provide cardiovascular benefits in some patients Evaluate your weight and BMI , particularly if weight management was a treatment goal Review your other diabetes medications to determine if adjustments or additions are needed Discuss your reasons for stopping , whether due to side effects, cost, injection concerns, or other factors If you and your healthcare provider decide that stopping Trulicity is appropriate, you will likely need an alternative treatment plan

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