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2019;8: e012244

However, whether these biochemical changes translate into meaningful clinical benefits remains uncertain

SURMOUNT-1 (Jastreboff 2022, NEJM) reported up to 20.9 percent average weight loss with tirzepatide versus 14.9 percent with semaglutide in STEP 1 (Wilding 2021, NEJM)

While many dietary supplements claim to lower cortisol and enhance weight loss, no studies have shown a clear link in cortisol reduction and weight loss
