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Derin Karacabeyli, MD, a rheumatologist and researcher at Vancouver General Hospital in British Columbia, agrees that theres limited data available about GLP-1s and RA

However, early on, it was noted that insulin derived from pancreatic extracts [1] or as crude insulin preparations [2] sometimes first elevated blood glucose and then later decreased blood glucose levels

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Now there are three main GLP-1 treatments that are legally available in the UK - Wegovy pill (oral semaglutide): This is the latest (MHRA-approved 11 June 2026) and the first oral GLP-1 weight loss tablet licensed in the UK