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Table of Contents How GLP-1 Affects Digestion and Gastric Emptying Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin hormone produced by L-cells in the small intestine in response to food intake

In clinical trials, hair loss was directly proportional to the rate and total amount of weight loss in people on the drugs

The hypothalamus, particularly the arcuate nucleus, contains GLP-1 receptors that modulate hunger and satiety signals

This is not a failureit reflects the biological drive to eat that the medication was helping to regulate

But there's a side effect most people aren't warned about: you're losing muscle, not just fat