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patients should be counseled to seek immediate medical attention for severe, persistent abdominal pain radiating to the back

Available clinical data indicate that adding cagrilintide to semaglutide does not substantially increase nausea or vomiting compared with semaglutide alone ( Management of GLP-1 induced nausea and vomiting The cornerstone of preventing nausea and vomiting with GLP-1based therapy is understanding that gastrointestinal adverse effects are primarily dose related rather than drug specific

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A better way to amend the pathophysiology of GLP-1 reported in diabetes or other diseases, would be to induce tissue specific de novo GLP-1 production, leading to a more physiological and likely safer, short and medium distance signaling