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The programme runs across four phases using the COM-B behaviour change model, covering nutrition, physical activity, sleep, and the psychological aspects of eating behaviour

Discuss all medications and supplements with your GP or pharmacist, as many commonly prescribed drugs (including certain antihypertensives, antidepressants, iron supplements, and opioid analgesics) can worsen constipation

These agents activate the cAMP-PKA signaling cascade in pancreatic -cells 6 , resulting in glucose-dependent insulin secretion, suppression of pancreatic -cell glucagon release, and modulation of gastrointestinal motility through delayed gastric emptying 7

Chronic central (intracerebroventricular) or peripheral (subcutaneous) infusion of GIP analogue in mice increased cFos neuronal activity in hypothalamic feeding center, resulting in reduced food intake and body weight

Funding This research was funded by National High Level Chinese Medicine Hospital Clinical Research Funding, grant number DFRC-YSZKTD2025-006