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These potential metabolic effects will need to be further characterised given the risk profile of the patient population of interest

Additionally, initial weight loss includes water and glycogen depletion, which accounts for faster loss early on

If pregnancy is not your goal, proactive planning matters

Merck and others are developing GLP-1s (MK-8521, orforglipron licensing, etc.), but as of 2026 none have announced capacity builds because their products are not yet commercial

Patients can access a wide range of GLP-1s Semaglutide injectable Oral semaglutide Tirzepatide injectable Oral tirzepatide GLP-1 weight management Phentermine weight management Testosterone therapy It was designed to be easy-to-use Due to increased demand, GLP-1s are often expensive