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Patients with higher body mass may have larger volumes of distribution, which could theoretically prolong elimination time, though this effect is generally modest compared to other factors

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There is no direct head-to-head trial, but the mechanistic difference, particularly the addition of glucagon receptor activity increasing energy expenditure, distinguishes the two compounds

Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial