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Most trials were in Phase 2 (40.7%) or Phase 3 (31.3%), indicating a maturing pipeline, while early-stage innovation remained limited (3.3% of trials)

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Retatrutide's triple mechanism changes this: The glucagon pathway activation actually SUPPORTS fat loss while helping preserve lean muscle mass

This approach highlights how nutritional substrates and metabolic cofactors may influence physiological resilience during sustained pharmacological weight reduction