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Research demonstrates that postmenopausal women experience a 9% decrease in total 24-hour energy expenditure and a 30% reduction in spontaneous physical activity energy expenditure.[1] The metabolic consequences are profound: estrogen deficiency worsens insulin resistance, which is further exacerbated by the age-related increase in cortisol that promotes gluconeogenesis

Conversely, inhibiting p38 MAPK reduces inflammation and fibrosis, potentially improving kidney function [79]

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When he studied the lizards venom, he discovered that its saliva contained a hormone called exendin-4, which worked much the same way as GLP-1, but lasted much longer