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Semaglutide, originally approved for diabetes treatment, has become a groundbreaking weight loss medication, offering significant results with an average 14.9% body weight reduction in clinical trials, though its high cost has led to increased interest in more affordable compounded versions, which should be obtained from reputable sources under proper medical supervision.

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The review urges nurse practitioners to balance expanding clinical promise with careful prescribing, patient education, monitoring, access advocacy, and vigilance for gastrointestinal, endocrine, pregnancy-related, and rare serious risks.

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