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DPP-4 inhibitors like sitagliptin/Januvia) that indirectly boost GLP-1 by stopping its degradation, but those are a different class

Current Nutrition Reports, 14(1), 63

Gut microbiota composition (including Firmicutes , Bacteroidetes , Akkermansia , and Bifidobacterium ) influences host metabolism by producing short-chain fatty acids (SCFAs), generating secondary bile acids, modulating immune and inflammatory pathways, and stimulating GLP-1 secretion from intestinal L-cells

Concerns about thyroid cancer risk and the potential for sarcopenia or bone fragility in older patients further underscore the need for long-term surveillance (Nunn et al., 2024)

However, the majority of individuals now receiving GLP-1 medications are using them for obesity management and do not have diabetes