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The potential to decrease burden of morbidity and mortality secondary to obesity, DM and cardiovascular diseases is a power GLP-1 RA can help harness to safe resources and improve quality of life as well as life span of populations at risk

Notably, the GLP-1R agonist liraglutide suppressed exogenous lactate-induced upregulation of the acetyltransferase p300, which has been identified as a writer of histone lactylation by transferring the lactyl group from lactyl-CoA to specific histone lysine residues [16]

Therefore, GLP-1RAs and GIP-RAs hold promise to be potential treatments for a wide variety of diseases

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