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Researchers estimated that roughly 67 patients would need to be treated to prevent one major cardiovascular event
In January 1989, the Novo Nordisk merger is finally announced
Peak drug concentration climbs steeply with each escalation before settling which is why GI side effects cluster during escalation windows and typically improve as each new dose level reaches steady state
Tsang, A
GI events are dose-dependent: nausea (15-44%), vomiting (5-24%), diarrhea (8-30%), and constipation (5-24%)
