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Ensuring adequate protein intake, maintaining nutritional supplementation, and avoiding excessive caloric restriction during transitions can help minimize this risk

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Several guidelines currently recommend GLP-1 RAs as add-on therapy to almost all diabetic treatments (with the exception of dipeptidyl peptidase-4 [DPP-4] inhibitors) and even as monotherapy to those intolerant to metformin

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In contrast, non-ATP-linked oxygen consumption tended to increase in cells exposed to irisin or Ex-4 compared to controls (Figure 5 B)