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Inspired by rat amylin, which is less prone to dimerize, the enhanced stability of pramlintide compared to human amylin was achieved by introducing three amino acid substitutions (pro25,28,29) into the sequence of human amylin ( Table 1 )

These drugs improve glucose control, reduce weight, and lower cardiovascular risk

Heres a link to a past post about a study that showed that bariatric surgery is more cost effective than GLP-1 drugs for obesity treatment

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