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Key Research Findings & Benefits Unprecedented Weight Loss Data: Clinical trials have demonstrated mean weight reductions of up to 24.2%, approaching bariatric surgery outcomes

People who have not achieved adequate weight loss with topiramate alone may benefit from adding semaglutide, though newer GLP-1 options like tirzepatide offer dual-receptor activation and potentially greater efficacy

Eligibility Basics Most blood centers assess diabetes by current health status, not by the diagnosis alone

Studies addressing this issue have had mixed results, and many study designs make it difficult to apply the results to specific patient types such as people living with obesity on calorierestricted diets

In models of compulsive overeating and food addiction, GLP-1RAs consistently decrease binge-like intake of high-fat/high-sugar foods, suppress operant responding for sucrose, and reduce cue-potentiated feeding behaviors [12]