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(2) SNAC molecules leave the aqueous cluster one at a time, incorporating into the membrane to form dynamic, SNAC-filled membrane defects, which allow semaglutide to bypass the barrier formed by the phospholipid head groups

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( 10.1126/scitranslmed.3007218) [DOI] [PubMed] [Google Scholar] Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, et al

Key Takeaway: While some large-scale data suggests a correlation between GLP-1 use and kidney stones, clinical observations also show that these medications may improve urinary chemistry in ways that prevent certain types of stones

doi: 10.1002/mds.25945 81 KouliATorsneyKMKuanW-L