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The trade-off is that slower escalation means slower weight loss initially, but the improved tolerability often leads to better long-term adherence and outcomes

It is not about weight loss

[DOI] [PubMed] [Google Scholar] 89.Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with type 2 diabetes

Therefore, potential selection bias cannot be excluded, and reproducibility is inherently limited compared to systematic analyses

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